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Protein Domain : GlmS/FrlB, SIS domain 2

Primary Identifier  IPR035490 Type  Domain
Short Name  GlmS/FrlB_SIS
description  This entry represents the SIS (Sugar ISomerase) domain 2 found in glucosamine 6-phosphate synthase (GlmS) and fructosamine deglycase FrlB.GlmS contains a N-terminal glutaminase domain and C-terminal isomerase domain (consisting of two SIS domains) []and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source []. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate [, , ].FrlB catalyses the conversion of a range of fructosamine 6-phosphates to glucose 6-phosphate and a free amino acid [].

0 Child Features

1 Parent Features

3 Protein Domain Regions