| First Author | Shi Y | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 12 | Pages | 1789-95 |
| PubMed ID | 21510938 | Mgi Jnum | J:173209 |
| Mgi Id | MGI:5013541 | Doi | 10.1016/j.febslet.2011.04.021 |
| Citation | Shi Y, et al. (2011) Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells. Correction. FEBS Lett 585(12):1789-95 |
| abstractText | Mesangial cell apoptosis contributes to the pathogenesis of diabetic nephropathy. Here we show that thioredoxin interacting protein (TXNIP) is involved in high glucose (HG)-induced mouse mesangial cell (MMC) apoptosis. HG induced activation of apoptosis signal regulating kinase-1 (ASK1) in a time-dependent manner in MMCs. Treatment with antioxidant, tempol, or knockdown of TXNIP in MMCs reduced HG-mediated apoptosis, expression of cleaved caspase-3, Bax/Bcl-2 ratio and activation of ASK1. These data suggest that knockdown of TXNIP prevented HG-induced cell apoptosis and activation of ASK1 may be via reduction of oxidative stress in MMCs. |
