Primary Identifier | MGI:5751220 | Allele Type | Targeted |
Attribute String | Dominant negative | Gene | Trex1 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The coding exon and 5'UTR were replaced with sequence with a C to T mutation in the 5' UTR and a D18N mutation in the exon and a floxed neo cassette was inserted in the 3' region via homologous recombination. Cre mediated recombination removed the neo cassette. |