| First Author | Xu L | Year | 2006 |
| Journal | Biochim Biophys Acta | Volume | 1759 |
| Issue | 11-12 | Pages | 503-13 |
| PubMed ID | 17182123 | Mgi Jnum | J:118611 |
| Mgi Id | MGI:3699974 | Doi | 10.1016/j.bbaexp.2006.11.001 |
| Citation | Xu L (2006) Regulation of Smad activities. Biochim Biophys Acta 1759(11-12):503-13 |
| abstractText | TGF-beta (Transforming Growth Factor-beta) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-beta stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression. The cytoplasm-to-nucleus redistribution of Smads, as well as the ability of Smads to activate or repress gene transcription, is under multiple layers of regulation by factors not limited to TGF-beta. With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-beta. |
