| First Author | Shi LJ | Year | 2022 |
| Journal | Genes (Basel) | Volume | 13 |
| Issue | 3 | PubMed ID | 35328064 |
| Mgi Jnum | J:342038 | Mgi Id | MGI:7486361 |
| Doi | 10.3390/genes13030510 | Citation | Shi LJ, et al. (2022) Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice. Genes (Basel) 13(3) |
| abstractText | Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. Apoe-null (Apoe(-/-)) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ Apoe(-/-) mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL Bglu20 for fasting and non-fasting glucose levels. Carotid lesion sizes showed a trend toward correlation with fasting and non-fasting glucose levels in F2 mice. The Chr15 QTL for carotid lesions was suppressed after excluding the influence from fasting or non-fasting glucose. Likely candidate genes for the causal association were Tnfrsf11b, Deptor, and Gsdmc2. These results demonstrate a causative role for hyperglycemia in the development of carotid atherosclerosis in hyperlipidemic mice. |
