| First Author | Sofia Beas B | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 6218 |
| PubMed ID | 33277492 | Mgi Jnum | J:300968 |
| Mgi Id | MGI:6504554 | Doi | 10.1038/s41467-020-19980-7 |
| Citation | Sofia Beas B, et al. (2020) A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding. Nat Commun 11(1):6218 |
| abstractText | Marked deficits in glucose availability, or glucoprivation, elicit organism-wide counter-regulatory responses whose purpose is to restore glucose homeostasis. However, while catecholamine neurons of the ventrolateral medulla (VLM(CA)) are thought to orchestrate these responses, the circuit and cellular mechanisms underlying specific counter-regulatory responses are largely unknown. Here, we combined anatomical, imaging, optogenetic and behavioral approaches to interrogate the circuit mechanisms by which VLM(CA) neurons orchestrate glucoprivation-induced food seeking behavior. Using these approaches, we found that VLM(CA) neurons form functional connections with nucleus accumbens (NAc)-projecting neurons of the posterior portion of the paraventricular nucleus of the thalamus (pPVT). Importantly, optogenetic manipulations revealed that while activation of VLM(CA) projections to the pPVT was sufficient to elicit robust feeding behavior in well fed mice, inhibition of VLM(CA)-pPVT communication significantly impaired glucoprivation-induced feeding while leaving other major counterregulatory responses intact. Collectively our findings identify the VLM(CA)-pPVT-NAc pathway as a previously-neglected node selectively controlling glucoprivation-induced food seeking. Moreover, by identifying the ventrolateral medulla as a direct source of metabolic information to the midline thalamus, our results support a growing body of literature on the role of the PVT in homeostatic regulation. |
