| First Author | Vogel I | Year | 2022 |
| Journal | Eur J Immunol | Volume | 52 |
| Issue | 10 | Pages | 1620-1629 |
| PubMed ID | 35856659 | Mgi Jnum | J:340035 |
| Mgi Id | MGI:7330300 | Doi | 10.1002/eji.202149698 |
| Citation | Vogel I, et al. (2022) Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production. Eur J Immunol |
| abstractText | CD27/CD70 costimulation enhances T-cell survival, memory formation and Th1-cell differentiation and effector function. In addition to promoting Th1 responses, CD27 signaling has been shown to exert a negative regulatory role on IL-17 production, resulting in increased sensitivity of CD27 KO mice to EAE. By inducing EAE in full CD27 KO mice, and in a novel, T-cell specific CD27 KO mouse strain (CD4-Cre x CD27(flox/flox) ), we demonstrate herein that CD27 engagement by its natural ligand (CD70) suppresses IL-17 production in a cell autonomous fashion. We further show that CD27 engagement by an agonistic antibody given after EAE induction or at symptom onset similarly suppresses IL-17 production by activated CD4(+) T cells infiltrating the inflamed CNS while IFN-gamma production was unaffected, leading to an amelioration of inflammatory-related symptoms. These findings propose CD27 costimulation as a potential candidate for therapeutic manipulation to treat autoimmune and autoinflammatory diseases characterized by excessive IL-17 production. |
