| First Author | Burchill MA | Year | 2015 |
| Journal | Eur J Immunol | Volume | 45 |
| Issue | 11 | Pages | 3140-9 |
| PubMed ID | 26179759 | Mgi Jnum | J:233044 |
| Mgi Id | MGI:5780642 | Doi | 10.1002/eji.201545749 |
| Citation | Burchill MA, et al. (2015) T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs. Eur J Immunol 45(11):3140-9 |
| abstractText | T cells compete against each other for access to molecules on APCs in addition to peptide/MHC complexes. However, the identity of cell surface molecules that influence T-cell competition, other than peptide/MHC, have yet to be defined. Here, we identify CD70, a TNF ligand expressed on activated APCs, as an important mediator of T-cell competition for APCs. Upon engagement of CD27 by CD70, CD27 is proteolytically cleaved from the surface of the interacting CD8(+) T cell and captured by CD70 expressing dendritic cells. The capture of CD27 effectively masks CD70 on APCs, disallowing the interaction with CD27 on other competing T cells. Collectively, our data indicate that T cells compete against each other for access to the TNF-ligand CD70, an interaction that affects the duration and potency of T cell/DC interactions, thus influencing the repertoire of responding CD8(+) T cells to self or foreign antigens. |
