| First Author | Schildknecht A | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 3 | Pages | 716-28 |
| PubMed ID | 17295392 | Mgi Jnum | J:118676 |
| Mgi Id | MGI:3700096 | Doi | 10.1002/eji.200636824 |
| Citation | Schildknecht A, et al. (2007) Priming of CD8(+) T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells. Eur J Immunol 37(3):716-28 |
| abstractText | The CD27/CD70-interaction has been shown to provide a costimulatory and survival signal for T cells in vitro and in vivo. Recently, CD70 expression by DC was found to be important for the priming of CD8(+) T cells. We show here that blocking CD70 interactions has a significant impact on priming of CD8(+) T cell responses by vaccinia virus (VV), Listeria monocytogenes and vesicular stomatitis virus (VSV) in mice. However, the priming of specific CD8(+) T cells upon infection with lymphocytic choriomeningitis virus (LCMV) was only marginally reduced by CD70-blockade. Blocking of CD70 prevented CD8(+) T cell priming in DIETER mice, a model in which presentation of LCMV-derived epitopes can be induced selectively in dendritic cells (DC). In contrast, CD70-CD27 interactions were not important for the priming of VSV-specific CD4(+) T cells or class switch of neutralizing antibodies. As we show that priming of CD8(+) T cells by the pathogens used here is dependent on antigen presentation by DC and that infection results in up-regulation of CD70 on DC, we conclude that CD70 expression on DC plays an important role in the priming of CD8(+) T cells by pathogens. Moreover, the lack of CD70 cannot be completely compensated for by other costimulatory molecules. |
