| First Author | van Gisbergen KP | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 9 | Pages | 5352-62 |
| PubMed ID | 19380782 | Mgi Jnum | J:147717 |
| Mgi Id | MGI:3842015 | Doi | 10.4049/jimmunol.0802809 |
| Citation | van Gisbergen KP, et al. (2009) Protective CD8 T cell memory is impaired during chronic CD70-driven costimulation. J Immunol 182(9):5352-62 |
| abstractText | Chronic infection results in continuous formation and exhaustion of effector CD8 T cells and in failure of memory CD8 T cell development. Expression of CD70 and other molecules that provide costimulation to T cells is maintained during chronic infection. To analyze the impact of constitutive CD70-driven costimulation, we generated transgenic mice expressing CD70 specifically on T cells. We show that CD70 promoted accumulation of CD8 T cells with characteristics strikingly similar to exhausted effector CD8 T cells found during chronic infection. CD70 on T cells provided costimulation that enhanced primary CD8 T cell responses against influenza. In contrast, memory CD8 T cell maintenance and protection against secondary challenge with influenza was impaired. Interestingly, we found no effect on the formation of either effector or memory CD4 T cells. We conclude that constitutive expression of CD70 is sufficient to deregulate the CD8 T cell differentiation pathway of acute infection reminiscent of events in chronic infection. |
