| First Author | Binder DK | Year | 2004 |
| Journal | Neuroreport | Volume | 15 |
| Issue | 2 | Pages | 259-62 |
| PubMed ID | 15076748 | Mgi Jnum | J:103525 |
| Mgi Id | MGI:3610259 | Doi | 10.1097/00001756-200402090-00009 |
| Citation | Binder DK, et al. (2004) Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport 15(2):259-62 |
| abstractText | Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge. In this report, we tested seizure susceptibility in AQP4 mice. AQP4 mice and wild-type controls were given the chemoconvulsant pentylenetetrazol (PTZ) and monitored for seizure activity. At 40 mg/kg PTZ, all wild-type mice exhibited seizure activity, whereas six of seven AQP4 mice did not exhibit seizure activity. At 50 mg/kg PTZ, both groups exhibited seizure activity; however, the latency to generalized (tonic-clonic) seizures was significantly lower in wild-type than AQP4 mice. These results suggest that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity. |
