| First Author | Sawatani Y | Year | 2008 |
| Journal | Int Immunol | Volume | 20 |
| Issue | 10 | Pages | 1259-68 |
| PubMed ID | 18653699 | Mgi Jnum | J:140227 |
| Mgi Id | MGI:3812293 | Doi | 10.1093/intimm/dxn082 |
| Citation | Sawatani Y, et al. (2008) The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int Immunol 20(10):1259-68 |
| abstractText | Regulation of dendritic cell (DC) function is critical for maintaining self-tolerance and preventing autoimmunity. The dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in cell-cell fusion of osteoclasts and foreign body giant cells, but though originally identified in DCs, its specific roles there remain undefined. Here, we report that aged DC-STAMP-deficient mice display several systemic autoimmune symptoms such as spontaneous lymphoproliferation, splenomegaly associated with infiltration of T cells in several organs and increased serum anti-double-stranded DNA antibody production. Although a lack of DC-STAMP did not inhibit DC differentiation or proliferation, antigen presentation activity of DC-STAMP-deficient DCs was significantly up-regulated in both class I and II pathways through increased phagocytotic activity compared with wild-type DCs, an activity likely leading to autoimmunity. Our results indicate that DC-STAMP is required for proper regulation of DC activity and maintenance of immune self-tolerance. |
