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Protein Coding Gene : Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor
Primary Identifier  MGI:1341864 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  18201
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable signaling adaptor activity and sphingomyelin phosphodiesterase activator activity. Involved in positive regulation of amide metabolic process; regulation of lipid metabolic process; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in plasma membrane. Is expressed in genitourinary system and thalamus mantle layer. Orthologous to human NSMAF (neutral sphingomyelinase activation associated factor).
PHENOTYPE: Mice homozygous for a targeted null mutation show no gross phenotypic abnormalities but display delayed cutaneous barrier repair. In addition, D-galactosamine-sensitized homozygotes are partially resistant to LPS- and TNF-induced lethality. [provided by MGI curators]
  • synonyms:
  • AA959567,
  • Fan,
  • EST AA959567,
  • MGI:2135553,
  • Nsmaf,
  • factor associated with N-SMase activation,
  • neutral sphingomyelinase (N-SMase) activation associated factor
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Trail: ProteinCodingGene

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