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Allele : Hpse<em1(cre)Ngai> heparanase; endonuclease-mediated mutation 1, John Ngai
Primary Identifier  MGI:7286051 Allele Type  Endonuclease-mediated
Attribute String  Epitope tag, Recombinase Gene  Hpse
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  true Is Wild Type  false
molecularNote  Using CRISPR/Cas9 technology, a P2A-Cre (encoding a viral 2A oligopeptide that mediates ribosomal skipping and a codon-optimized cre gene) and a myc-tag were inserted into the targetted STOP codon of the Heparanase gene (Hpse) on chromosome 9 in embryonic stem cells. Chimeric mice were generated by aggregating ES cells with morula-stage embryos and bred for germline transmission.
  • mutations:
  • Insertion
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