| First Author | Matsumoto M | Year | 2013 |
| Journal | Infect Immun | Volume | 81 |
| Issue | 7 | Pages | 2518-27 |
| PubMed ID | 23630966 | Mgi Jnum | J:199724 |
| Mgi Id | MGI:5504547 | Doi | 10.1128/IAI.00285-13 |
| Citation | Matsumoto M, et al. (2013) IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection. Infect Immun 81(7):2518-27 |
| abstractText | The host deploys a subset of immune responses to expel helminths, which differs depending on the nature of the helminth. Strongyloides venezuelensis, a counterpart of the human pathogen S. stercoralis, naturally infects rodents and has been used as an experimental model. Here we show that induction of immunoglobulin G (IgG) and IgE is a prerequisite for rapid expulsion of S. venezuelensis during a primary infection. Activation-induced cytidine deaminase-deficient (AID(-/-)) mice, which lack the ability to switch IgM to other isotypes, normally developed T-helper 2 (Th2) cells and intestinal mastocytosis after infection with S. venezuelensis. Although AID(-/-) mice expelled Nippostrongylus brasiliensis normally, they required a much longer period to expel S. venezuelensis than wild-type (WT) mice. Adoptive transfers of immune sera from S. venezuelensis-infected but not N. brasiliensis-infected mice restored the ability of AID(-/-) mice to promptly expel S. venezuelensis. Immune serum-derived IgG and IgE induced worm expulsion via Fc gamma receptor III (FcgammaRIII) and Fc epsilon receptor I (FcepsilonRI), respectively, and a mixture of IgG and IgE showed collaborative effects. Whereas FcgammaRIII(-/-) mice or FcepsilonRIalpha(-/-) mice normally could expel S. venezuelensis, FcgammaRIII(-/-) mice, when their IgE was neutralized by anti-IgE, or FcepsilonRIalpha(-/-) mice, when their IgG binding to FcgammaRIII was blocked by anti-FcgammaRIII, showed a markedly reduced ability to expel S. venezuelensis. These data reveal that IgG and IgE play redundant roles but act in concert to accelerate S. venezuelensis expulsion. Mast cell-deficient mice, even those equipped with immune serum-derived IgG or IgE, failed to expel S. venezuelensis promptly, suggesting that mast cells are cellular targets of IgG and IgE. |
