| Primary Identifier | MGI:1929004 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 58231 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in hippo signaling and positive regulation of substrate-dependent cell migration, cell attachment to substrate. Acts upstream of or within several processes, including embryonic organ development; epithelial tube morphogenesis; and positive regulation of apoptotic process. Located in cytoplasm and nucleus. Is expressed in ovary; renal vasculature; and testis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human STK4 (serine/threonine kinase 4). PHENOTYPE: Mice homozygous for a gene trap allele have low numbers of naïve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
