| First Author | Yasuda K | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 1 | Pages | 68-75 |
| PubMed ID | 26787462 | Mgi Jnum | J:229973 |
| Mgi Id | MGI:5755180 | Doi | 10.1002/1873-3468.12045 |
| Citation | Yasuda K, et al. (2016) Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency. FEBS Lett 590(1):68-75 |
| abstractText | Mammalian ste-20 like kinase Mst1 plays important roles during apoptosis, proliferation, cell polarity, and migration. Here, we report a novel role of Mst1 for cytotoxic T-cell responses and tumor suppression. The defect of Mst1 caused decreased levels of FoxO, and promoted cytotoxicity in vitro. Mst1(-/-) cytotoxic T cells also exhibited enhanced T-bet expression that was associated with elevated expression levels of IFNgamma and granzyme B. Moreover, Mst1(-/-) cytotoxic T cells suppressed tumor growth in vivo. The data suggest that Mst1 inhibits cytotoxicity via T-bet suppression by FoxO1 and FoxO3a. Thus, Mst1 is a potential therapeutic target for tumor immunotherapy. |
