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Publication : Telomeric DNA mediates de novo PML body formation.

First Author  Brouwer AK Year  2009
Journal  Mol Biol Cell Volume  20
Issue  22 Pages  4804-15
PubMed ID  19793919 Mgi Jnum  J:238456
Mgi Id  MGI:5819345 Doi  10.1091/mbc.E09-04-0309
Citation  Brouwer AK, et al. (2009) Telomeric DNA mediates de novo PML body formation. Mol Biol Cell 20(22):4804-15
abstractText  The cell nucleus harbors a variety of different bodies that vary in number, composition, and size. Although these bodies coordinate important nuclear processes, little is known about how they are formed. Among the most intensively studied bodies in recent years is the PML body. These bodies have been implicated in gene regulation and other cellular processes and are disrupted in cells from patients suffering from acute promyelocytic leukemia. Using live cell imaging microscopy and immunofluorescence, we show in several cell types that PML bodies are formed at telomeric DNA during interphase. Recent studies revealed that both SUMO modification sites and SUMO interaction motifs in the promyelocytic leukemia (PML) protein are required for PML body formation. We show that SMC5, a component of the SUMO ligase MMS21-containing SMC5/6 complex, localizes temporarily at telomeric DNA during PML body formation, suggesting a possible role for SUMO in the formation of PML bodies at telomeric DNA. Our data identify a novel role of telomeric DNA during PML body formation.
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