| First Author | Al-Shami A | Year | 2005 |
| Journal | J Exp Med | Volume | 202 |
| Issue | 6 | Pages | 829-39 |
| PubMed ID | 16172260 | Mgi Jnum | J:107431 |
| Mgi Id | MGI:3621221 | Doi | 10.1084/jem.20050199 |
| Citation | Al-Shami A, et al. (2005) A role for TSLP in the development of inflammation in an asthma model. J Exp Med 202(6):829-39 |
| abstractText | Thymic stromal lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cell homeostasis. We now demonstrate that TSLP is required to mount a normal CD4+ T cell-mediated inflammatory response. TSLP acts directly on naive, but not, memory CD4+ T cells, and promotes their proliferation in response to antigen. In addition, TSLP exerts an effect indirectly through DCs to promote Th2 differentiation of CD4+ T cells. Correspondingly, TSLP receptor (TSLPR) knockout (KO) mice exhibit strong Th1 responses, with high levels of interleukin (IL)-12, interferon-gamma, and immunoglobulin (Ig) G2a, but low production of IL-4, -5, -10, -13, and IgE; moreover, CD4+ T cells from these animals proliferate less well in response to antigen. Furthermore, TSLPR KO mice fail to develop an inflammatory lung response to inhaled antigen unless supplemented with wild-type CD4+ T cells. This underscores an important role for this cytokine in the development of inflammatory and/or allergic responses in vivo. |
