| Primary Identifier | IPR038493 | Type | Homologous_superfamily |
| Short Name | MqsR_sf |
| description | MqsR is a bacterial toxin that acts as an mRNA interferase []. MqsR is the gene most highly upregulated in E. coli persister cells []and it plays an essential role in biofilm regulation []and cell signalling []. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows thatit is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterised bacterial toxins []. |
