| Primary Identifier | IPR032569 | Type | Domain |
| Short Name | NPM1_C |
| description | This domain, approximately 50 residues in length, is mainly found in C-terminal region of nucleophosmin from animals []. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli []. Although it shuttles rapidly between the nucleus and the cytoplasm, a large fraction of NPM1/B23 resides in the nucleoli []. Mutations of the NPM1 gene has been linked to acute myeloid leukemia []. This domain has a three-helix bundle which binds the G-quadruplex DNA at the interface between helices H1 and H2 through electrostatic interactions with the G-quadruplex phosphate backbone [, ]. |
