| First Author | Nus M | Year | 2017 |
| Journal | Nat Med | Volume | 23 |
| Issue | 5 | Pages | 601-610 |
| PubMed ID | 28414328 | Mgi Jnum | J:251856 |
| Mgi Id | MGI:6103395 | Doi | 10.1038/nm.4315 |
| Citation | Nus M, et al. (2017) Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med 23(5):601-610 |
| abstractText | Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol diet (HCD) and regulate both the differentiation and accumulation of T follicular helper (TFH) cells. Feeding mice an HCD resulted in upregulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner and increased the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and suppression of the proatherogenic TFH response. Our findings reveal a previously unsuspected role for MZB cells in controlling the TFH-germinal center response to a cholesterol-rich diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immune properties to limit an exaggerated adaptive immune response. |
