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Allele : Nbn<tm2.1Jpt> nibrin; targeted mutation 2.1, John H Petrini

Primary Identifier  MGI:3771078 Allele Type  Targeted
Attribute String  Null/knockout Gene  Nbn
Transmission  Germline Strain of Origin  129/Sv
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted into intron 14 and additional loxP site was inserted into intron 15. Cre mediated recombination was used to remove the neo cassette and exon 15. The protein product lacks the last 24 amino acids that contains the ATM binding domain. The presence of a shortened protein product was confirmed by western blot analysis on extracts from mouse embryonic fibroblasts.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Nbs1<deltaC>,
  • Nbs1<deltaC>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

7 Publication categories

Trail: Allele