| First Author | Lozano-Velasco E | Year | 2015 |
| Journal | Mol Cell Biol | Volume | 35 |
| Issue | 17 | Pages | 2892-909 |
| PubMed ID | 26055324 | Mgi Jnum | J:228240 |
| Mgi Id | MGI:5705702 | Doi | 10.1128/MCB.00536-15 |
| Citation | Lozano-Velasco E, et al. (2015) A Pitx2-MicroRNA Pathway Modulates Cell Proliferation in Myoblasts and Skeletal-Muscle Satellite Cells and Promotes Their Commitment to a Myogenic Cell Fate. Mol Cell Biol 35(17):2892-909 |
| abstractText | The acquisition of a proliferating-cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite cell proliferation is regulated is not fully understood. Here, we report that the c-isoform of the transcription factor Pitx2 increases cell proliferation in myoblasts by downregulating microRNA 15b (miR-15b), miR-23b, miR-106b, and miR-503. This Pitx2c-microRNA (miRNA) pathway also regulates cell proliferation in early-activated satellite cells, enhancing Myf5(+) satellite cells and thereby promoting their commitment to a myogenic cell fate. This study reveals unknown functions of several miRNAs in myoblast and satellite cell behavior and thus may have future applications in regenerative medicine. |
