| First Author | Beermann F | Year | 1993 |
| Journal | Mech Dev | Volume | 42 |
| Issue | 1-2 | Pages | 59-65 |
| PubMed ID | 8103668 | Mgi Jnum | J:13268 |
| Mgi Id | MGI:61474 | Doi | 10.1016/0925-4773(93)90098-i |
| Citation | Beermann F, et al. (1993) Perinatal activation of a tyrosine aminotransferase fusion gene does not occur in albino lethal mice. Mech Dev 42(1-2):59-65 |
| abstractText | To investigate developmental expression of the rat tyrosine aminotransferase (TAT) gene in normal and in albino lethal mice we generated transgenic mice carrying a fusion gene of TAT 5'-sequences (11 kb) and the bacterial chloramphenicol acetyltransferase (CAT) gene. In four lines, CAT activity was found only in liver. RNA analyses on a high-expressing line showed that transgenic expression follows expression of mouse TAT mRNA: it is inducible by glucocorticoids and activated perinatally. This perinatal activation of transgene expression does not occur in lethal albino mice (c14CoS/c14CoS) which are characterized by reduced mRNA levels of several liver-specific enzymes involved in gluconeogenesis. In conclusion, the data show that the 5'-flanking region of the rat TAT gene contains elements specifying regulated expression and establish that the 5'-flanking region of the TAT gene is responsive to the enzyme deficiency characteristic of the albino lethal mice. |
