| First Author | Visvanathan J | Year | 2007 |
| Journal | Genes Dev | Volume | 21 |
| Issue | 7 | Pages | 744-9 |
| PubMed ID | 17403776 | Mgi Jnum | J:120378 |
| Mgi Id | MGI:3706460 | Doi | 10.1101/gad.1519107 |
| Citation | Visvanathan J, et al. (2007) The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 21(7):744-9 |
| abstractText | Neuronal gene expression is tightly regulated in developing CNS. Here, we demonstrate the anti-neural function of phosphatase SCP1 (small C-terminal domain phosphatase 1) during development. We further show that the neuron-enriched microRNA miR-124 directly targets SCP1-3' untranslated region (UTR) to suppress SCP1 expression. In developing spinal cord, expression of miR-124 and SCP1 is complementary, and miR-124 antagonism phenocopies SCP1 overexpression and vice versa. In P19 cells, miR-124 suppresses SCP1 expression and induces neurogenesis, and SCP1 counteracts this proneural activity of miR-124. Our results suggest that, during CNS development, timely down-regulation of SCP1 is critical for inducing neurogenesis, and miR-124 contributes to this process at least in part by down-regulating SCP1 expression. |
