| First Author | Gouras P | Year | 1991 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 32 |
| Issue | 13 | Pages | 3167-74 |
| PubMed ID | 1748547 | Mgi Jnum | J:607 |
| Mgi Id | MGI:49143 | Citation | Gouras P, et al. (1991) Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest Ophthalmol Vis Sci 32(13):3167-74 |
| abstractText | Dissociated photoreceptor cells from a transgenic strain of mice, containing a bovine promoter lac Z gene construct, were transplanted to the dystrophic retinas of a strain of mice (C3H, rd/rd) without obvious photoreceptors. The transgenic photoreceptor cells expressed beta-galactosidase and were distinguishable from the host retinal cells by light and electron microscopy after the 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside histochemical reaction. These results showed that transplanted transgenic photoreceptor cells survived at least 1 month in the host retina and had a primitive outer segment and a well-developed synaptic terminal. |
