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Publication : Spatio-temporal pattern of ocular clusterin mRNA expression in the rd mouse.

First Author  Jomary C Year  1995
Journal  Brain Res Mol Brain Res Volume  29
Issue  1 Pages  172-6
PubMed ID  7769994 Mgi Jnum  J:23289
Mgi Id  MGI:71054 Doi  10.1016/0169-328x(94)00252-a
Citation  Jomary C, et al. (1995) Spatio-temporal pattern of ocular clusterin mRNA expression in the rd mouse. Brain Res Mol Brain Res 29(1):172-6
abstractText  To define the relationship between progressive photoreceptor degeneration and clusterin upregulation, we analysed the spatio-temporal distribution and level of clusterin mRNA in the retinal degeneration (rd) mouse. Expression was increased in the retinal pigment epithelium and inner retina, but not detected in the photoreceptors. These results indicate that increased clusterin mRNA is not causally involved in apoptotic mechanisms of photoreceptor death but may relate to lipid-recycling or cytoprotective functions.
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