| First Author | Valeri N | Year | 2014 |
| Journal | Cancer Cell | Volume | 25 |
| Issue | 4 | Pages | 469-83 |
| PubMed ID | 24735923 | Mgi Jnum | J:210629 |
| Mgi Id | MGI:5571543 | Doi | 10.1016/j.ccr.2014.03.006 |
| Citation | Valeri N, et al. (2014) MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell 25(4):469-83 |
| abstractText | MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression. We show that miR-135b upregulation is common in sporadic and inflammatory bowel disease-associated human CRCs and correlates with tumor stage and poor clinical outcome. Inhibition of miR-135b in CRC mouse models reduces tumor growth by controlling genes involved in proliferation, invasion, and apoptosis. We identify miR-135b as a key downsteam effector of oncogenic pathways and a potential target for CRC treatment. |
