| First Author | Zhang L | Year | 2013 |
| Journal | Cancer Lett | Volume | 331 |
| Issue | 2 | Pages | 230-8 |
| PubMed ID | 23340180 | Mgi Jnum | J:194341 |
| Mgi Id | MGI:5473457 | Doi | 10.1016/j.canlet.2013.01.003 |
| Citation | Zhang L, et al. (2013) MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer Lett 331(2):230-8 |
| abstractText | Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis revealed that miR-135b affects a regulator that inhibits hypoxia-inducible factor (HIF). Increased miR-135b expression was positively correlated with HIF-1alpha expression and microvessel density in the HNSCC model. Thus, our data demonstrate that miR-135b acts as a tumor promoter by promoting cancer cell proliferation, colony formation, survival, and angiogenesis through activation of HIF-1alpha in HNSCC. |
