| First Author | Carter-Dawson LD | Year | 1978 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 17 |
| Issue | 6 | Pages | 489-98 |
| PubMed ID | 659071 | Mgi Jnum | J:5988 |
| Mgi Id | MGI:54465 | Citation | Carter-Dawson LD, et al. (1978) Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98 |
| abstractText | The retinas of rd/rd C57BL/6J-rd le mice have been examined by light and electron microscopy to determine whether rod cell degeneration precedes cone cell degeneration. In all regions of the eye, a rapid rod degeneration precedes a much slower cone degeneration. Only about 2% of the rods remain in the posterior region at postnatal day 17, and none by the day 36. By contrast, at least 75% of the cone nuclei remain at day 17. Although most of these slowly disappear, about 1.5% of the original population of cone nuclei in the posterior retina is still present at 18 months of age. A central to peripheral temporal gradient of degeneration exists, such that some rod nuclei persist in the far periphery up to day 47, but none is found at day 65. About 5% of the cone nuclei are still present in the far periphery at 18 months of age. |
