| First Author | Dewamitta SR | Year | 2014 |
| Journal | Br J Haematol | Volume | 164 |
| Issue | 2 | Pages | 280-5 |
| PubMed ID | 24383846 | Mgi Jnum | J:210105 |
| Mgi Id | MGI:5569566 | Doi | 10.1111/bjh.12578 |
| Citation | Dewamitta SR, et al. (2014) Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors. Br J Haematol 164(2):280-5 |
| abstractText | Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARgamma(-/-) mice were anaemic, however, Epor-Cre Rara(fl/fl) , Epor-Cre Rarg(fl/fl) and Epor-Cre Rara(fl/fl) g(fl/fl) mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis. |
