| First Author | Musette P | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 8 | Pages | 1707-11 |
| PubMed ID | 8765010 | Mgi Jnum | J:35207 |
| Mgi Id | MGI:82660 | Doi | 10.1002/eji.1830260807 |
| Citation | Musette P, et al. (1996) Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice. Eur J Immunol 26(8):1707-11 |
| abstractText | The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3(+) T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline- injected MRL lpr/lpr controls, UDA-treated animals did not develop overt clinical signs of lupus and nephritis. The pathogenic T cell clones thus reside within the V beta 8.3(+) T cell population, which includes an expanded T cell clone described previously. Finally, UDA alters the production of autoantibodies in a sex-dependent manner. |
