| First Author | Carriba P | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 29111976 | Mgi Jnum | J:254961 |
| Mgi Id | MGI:6110894 | Doi | 10.7554/eLife.30442 |
| Citation | Carriba P, et al. (2017) CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. Elife 6:e30442 |
| abstractText | Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in Cd40(-/-) mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed in excitatory and inhibitory neurons cultured from Cd40(-/-) mice and were rescued by soluble CD40. The changes in excitatory and inhibitory neurons cultured from Cd40(-/-) mice were mimicked in neurons of Cd40(+/+) mice by treatment with soluble CD40L and were dependent on PKC-beta and PKC-gamma, respectively. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms. |
