| First Author | Armstrong E | Year | 1993 |
| Journal | Genes Chromosomes Cancer | Volume | 7 |
| Issue | 3 | Pages | 144-51 |
| PubMed ID | 7687867 | Mgi Jnum | J:12751 |
| Mgi Id | MGI:60970 | Doi | 10.1002/gcc.2870070306 |
| Citation | Armstrong E, et al. (1993) FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t(2;5), t(5;6), and t(3;5) translocations. Genes Chromosomes Cancer 7(3):144-51 |
| abstractText | FLT4 is a recently cloned receptor tyrosine kinase cDNA, which is characterized by seven immunoglobulin-like loops in its extracellular domain. We have previously mapped the FLT4 gene to chromosome segment 5q33-qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fluorescence in situ hybridization and show that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki-I-positive lymphomas, as well as to chromosome 3 in the t(3;5)(q25.1;q34) translocation, which is occasionally found in myelodysplastic syndromes and acute myeloid leukemia. No evidence was obtained for a rearrangement or deregulation of the translocated FLT4 gene. We further show that abundant FLT4 mRNA expression occurs only in erythroid and megakaryoblastoid cell lines among nine leukemia cell lines studied. |
