| First Author | Beland JL | Year | 1999 |
| Journal | J Neuroimmunol | Volume | 94 |
| Issue | 1-2 | Pages | 122-6 |
| PubMed ID | 10376944 | Mgi Jnum | J:102971 |
| Mgi Id | MGI:3608284 | Doi | 10.1016/s0165-5728(98)00238-0 |
| Citation | Beland JL, et al. (1999) B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality. J Neuroimmunol 94(1-2):122-6 |
| abstractText | We studied the susceptibility of B cell-deficient mice to encephalomyelitis following intraperitoneal inoculation of HSV-1. B cell-deficient mice developed striking CNS signs including tail atony, clumsy gait and limb paralysis after HSV-1 infection. In addition, B cell-deficient mice had decreased survival (LD50 = 2.2 x 10(7) PFU) compared to control C57BL/6 mice (LD50 = 2.3 x 10(8) PFU). B cell-deficient mice had encephalomyelitis and detectable virus in the brain 7 days post-infection while C57BL/6 mice did not. Passive transfer of hyperimmune sera protected B cell-deficient mice from death, suggesting a role for antibody in susceptibility to HSV-1 encephalomyelitis. |
