| Primary Identifier | MGI:6151434 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Dmp1-PTH1R*H223R)564Btm |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgenic construct contains a mouse Dmp1 promoter, including 8kb of the 5' flanking region, the first exon, the first intron, and 17 bp of exon 2, followed by a modified human PTHR1 gene, and a rabbit beta-globin polyA sequence. PTHR1 contains a histidine to arginine substitution at residue 223 (H223R or c.668A>G); the substitution results in constitutively active expression of PTHR1. |
