| First Author | Yu CR | Year | 2004 |
| Journal | Neuron | Volume | 42 |
| Issue | 4 | Pages | 553-66 |
| PubMed ID | 15157418 | Mgi Jnum | J:124299 |
| Mgi Id | MGI:3721301 | Doi | 10.1016/s0896-6273(04)00224-7 |
| Citation | Yu CR, et al. (2004) Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42(4):553-66 |
| abstractText | We have developed a genetic approach to examine the role of spontaneous activity and synaptic release in the establishment and maintenance of an olfactory sensory map. Conditional expression of tetanus toxin light chain, a molecule that inhibits synaptic release, does not perturb targeting during development, but neurons that express this molecule in a competitive environment fail to maintain appropriate synaptic connections and disappear. Overexpression of the inward rectifying potassium channel, Kir2.1, diminishes the excitability of sensory neurons and more severely disrupts the formation of an olfactory map. These studies suggest that spontaneous neural activity is required for the establishment and maintenance of the precise connectivity inherent in an olfactory sensory map. |
