| Primary Identifier | MGI:3618746 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 723959 |
| Mgi Type | miRNA gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including heart development; negative regulation of cardiac muscle cell proliferation; and post-transcriptional regulation of gene expression. Part of RISC complex. Is expressed in several structures, including brain; early conceptus; heart; oocyte; and somite. Orthologous to human MIR1-2 (microRNA 1-2). PHENOTYPE: Homozygous null mice show pericardial edema and impaired cardiac morphogenesis and electrophysiology, including ventricular septal defects in a subset that suffer early lethality, and reduced heart rate and cell cycle defects leading to hyperplasia in surviving adults. About 50% die by weaning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
