| First Author | Chen H | Year | 2017 |
| Journal | PLoS One | Volume | 12 |
| Issue | 6 | Pages | e0178969 |
| PubMed ID | 28591208 | Mgi Jnum | J:246115 |
| Mgi Id | MGI:5918916 | Doi | 10.1371/journal.pone.0178969 |
| Citation | Chen H, et al. (2017) AKT and its related molecular feature in aged mice skin. PLoS One 12(6):e0178969 |
| abstractText | Previous studies suggest that Akt signaling promotes tissue regeneration and decreased Akt activities are found in aged tissues. However, this study finds that the expression and activation levels of Akt in the mice skin increased with age. Additionally, the expression levels of Pten, p16, p21 and p53 also elevated with increased age. Immuno-fluorescence analysis showed that Akt phosphorylation found in the epidermal cells (with increased levels of NF-kappaB activation) were also found. In vivo inhibition of AKT activity result in reduced NF-kappaB activation. Our results suggest that increasing Akt/ NF-kappaB is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation. |
