First Author | Rensen S | Year | 2000 |
Journal | Cytogenet Cell Genet | Volume | 89 |
Issue | 3-4 | Pages | 225-9 |
PubMed ID | 10965129 | Mgi Jnum | J:64406 |
Mgi Id | MGI:1889183 | Doi | 10.1159/000015619 |
Citation | Rensen S, et al. (2000) Structure and chromosome location of Smtn, the mouse smoothelin gene. Cytogenet Cell Genet 89(3-4):225-9 |
abstractText | Smoothelins are cytoskeleton-associated proteins that are found in contractile smooth muscle. Two isoforms have been identified: smoothelin-A, expressed in visceral tissues and smoothelin-B, found in vascular tissues. The mouse smoothelin gene (Smtn) was isolated and characterized. It was assigned to chromosome 11 band A2-A3 by fluorescence in situ hybridization. The gene consists of 20 exons and spans 23 kb. Its structure is conserved between mouse and human. The proximal promoter of both smoothelin-A and smoothelin-B contains several transcription factor-binding sites but lacks a consensus TATA box. Copyright 2000 S. Karger AG, Basel. |