| First Author | Klugbauer N | Year | 2000 |
| Journal | FEBS Lett | Volume | 470 |
| Issue | 2 | Pages | 189-97 |
| PubMed ID | 10734232 | Mgi Jnum | J:61323 |
| Mgi Id | MGI:1354787 | Doi | 10.1016/s0014-5793(00)01306-5 |
| Citation | Klugbauer N, et al. (2000) A family of gamma-like calcium channel subunits. FEBS Lett 470(2):189-97 |
| abstractText | The gamma subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further gamma subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative gamma subunits that are predominantly expressed in brain. The gamma-2 and gamma-4 subunits shift the steady-state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type alpha(1A) subunit. The coexpression of the gamma-5 subunit accelerates the time course of current activation and inactivation of the alpha(1G) T-type calcium channel. |
