| First Author | Chaix J | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 3 | Pages | 1627-31 |
| PubMed ID | 18641298 | Mgi Jnum | J:137856 |
| Mgi Id | MGI:3803063 | Doi | 10.4049/jimmunol.181.3.1627 |
| Citation | Chaix J, et al. (2008) Cutting edge: Priming of NK cells by IL-18. J Immunol 181(3):1627-31 |
| abstractText | Recent evidence suggests that NK cells require priming to display full effector activity. In this study, we demonstrate that IL-18 contributed to this phenomenon. IL-18 signaling-deficient NK cells were found to be unable to secrete IFN-gamma in response to ex vivo stimulation with IL-12. This was not due to a costimulatory role of IL-18, because blocking IL-18 signaling during the ex vivo stimulation with IL-12 did not alter IFN-gamma production by wild-type NK cells. Rather, we demonstrate that IL-18 primes NK cells in vivo to produce IFN-gamma upon subsequent stimulation with IL-12. Importantly, IL-12-induced IFN-gamma transcription by NK cells was comparable in IL-18 signaling-deficient and -sufficient NK cells. This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines. |
