| Primary Identifier | MGI:1098776 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16803 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipopolysaccharide binding activity and signaling receptor binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of metabolic process; and response to bacterium. Acts upstream of or within leukocyte chemotaxis involved in inflammatory response; positive regulation of chemokine production; and positive regulation of neutrophil chemotaxis. Located in cell surface and extracellular space. Is expressed in brain; heart ventricle; liver lobe; and reproductive system. Orthologous to human LBP (lipopolysaccharide binding protein). PHENOTYPE: Homozygous mice have a generally normal phenotype but have an increased sensitivity to infection by gram negative bacteria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
