| First Author | Weber JR | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 2 | Pages | 269-79 |
| PubMed ID | 12932360 | Mgi Jnum | J:139341 |
| Mgi Id | MGI:3807766 | Doi | 10.1016/s1074-7613(03)00205-x |
| Citation | Weber JR, et al. (2003) Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity 19(2):269-79 |
| abstractText | Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in the CSF of patients with meningitis, and LBP-deficient mice failed to develop meningeal inflammation. LBP enhanced PCW-induced cell signaling and TNF-alpha release. LBP bound specifically to PCW multimers, indicating novel lipid-independent binding capability for LBP. We propose the iterative anionic groups along the glycan backbone of the cell wall are a crucial structure for recognition by LBP. Such a function for LBP expands its role to Gram-positive infections. |
