| First Author | Socher SH | Year | 1988 |
| Journal | J Exp Med | Volume | 167 |
| Issue | 6 | Pages | 1957-62 |
| PubMed ID | 3385359 | Mgi Jnum | J:36390 |
| Mgi Id | MGI:83823 | Doi | 10.1084/jem.167.6.1957 |
| Citation | Socher SH, et al. (1988) Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice. J Exp Med 167(6):1957-62 |
| abstractText | We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-dependent reductions in both food intake and weight were induced by rHuTNF. However, in spite of continued exposure to rHuTNF, the mice developed a resistance to rHuTNF and resumed their pretreatment food intake and weight. Non-immunological factors may play a role in the development of this tolerance, since it developed rapidly and faded within 2 wk of cessation of exposure to rHuTNF. |
