| First Author | Kapsimali M | Year | 2001 |
| Journal | J Comp Neurol | Volume | 431 |
| Issue | 3 | Pages | 276-92 |
| PubMed ID | 11170005 | Mgi Jnum | J:67214 |
| Mgi Id | MGI:1930065 | Doi | 10.1002/1096-9861(20010312)431:3<276::aid-cne1070>3.0.co;2-s |
| Citation | Kapsimali M, et al. (2001) Distribution of the orphan nuclear receptor Nurr1 in medaka (Oryzias latipes): Cues to the definition of homologous cell groups in the vertebrate brain. J Comp Neurol 431(3):276-92 |
| abstractText | The orphan nuclear receptor Nurr1 has been extensively studied in mammals and shown to contribute to the differentiation of several cell phenotypes in the nervous and endocrine systems. In this study, the gene homologous to the mammalian Nurr1 (NR4A2) was isolated in the teleost fish medaka (Oryzias latipes), and the distribution of its transcripts was analyzed within brains of embryos and adults. Nurr1 has a widespread distribution in the medaka brain. Large amounts of Nurr1 transcripts were found in the intermediate nucleus of the ventral telencephalon, preoptic magnocellular nucleus, ventral habenula, nucleus of the periventricular posterior tuberculum, and nuclei of glossopharyngeal and vagus nerves. To search for homologous cell groups between teleost fish and tetrapods brains, the co-localization of Nurr1 and tyrosine hydroxylase (TH) transcripts was analyzed. Neither Nurr1 nor TH expression was detected in the ventral midbrain, but both transcripts were present in the periventricular nucleus of the posterior tuberculum. This observation supports the hypothesis that this nucleus is homologous to dopaminergic mesencephalic nuclei of mammals. The presence of Nurr1 in the preoptic magnocellular nucleus of medaka and paraventricular hypothalamic nucleus of mammals reinforces the hypothesis of homology between these areas. TH and Nurr1 transcripts are also co-localized, among others, in the nucleus of the paraventricular organ and nucleus of the vagus nerve. This work suggests that the differentiating role of Nurr1 in the central nervous system is conserved in gnathostomes. Copyright 2001 Wiley-Liss, Inc. |
