| Primary Identifier | MGI:96976 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 17313 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be involved in branching morphogenesis of an epithelial tube; lung development; and protein-containing complex assembly. Predicted to act upstream of or within cartilage development; cell differentiation; and ossification. Predicted to be located in collagen-containing extracellular matrix and extracellular space. Predicted to be part of protein-containing complex. Predicted to be active in extracellular matrix. Is expressed in several structures, including genitourinary system; heart; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein). PHENOTYPE: Homozygotes for a targeted null mutation exhibit growth plate calcification leading to reduced stature, osteopenia, and fractures, and arterial calcification and rupture resulting in death by eight weeks of age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
