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Allele : Brca2<tm3.1Sks> breast cancer 2, early onset; targeted mutation 3.1, Shyam K Sharan
Primary Identifier  MGI:7565556 Allele Type  Targeted
Attribute String  Hypomorph Gene  Brca2
Transmission  Germline Strain of Origin  (C57BL/6J x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  An AGG to CAG change resulting in an arginine to glutamine substitution at amino acid 2971 (p.R2971Q) was introduced in exon 24. A loxP-PGK-Tn5-neomycin-bp(A)-loxP site cassette was inserted in intron 24. The neomycin cassette was removed via cre-mediated recombination. This is equivalent to R3052Q in human BRCA2.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Brca2<R2971Q>,
  • Brca2<RQ>,
  • Brca2<R2971Q>,
  • Brca2<RQ>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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