| First Author | Sheng M | Year | 2000 |
| Journal | J Cell Sci | Volume | 113 ( Pt 11) |
| Pages | 1851-6 | PubMed ID | 10806096 |
| Mgi Jnum | J:62923 | Mgi Id | MGI:1860053 |
| Doi | 10.1242/jcs.113.11.1851 | Citation | Sheng M, et al. (2000) The shank family of scaffold proteins. J Cell Sci 113(Pt 11):1851-6 |
| abstractText | Shank proteins make up a new family of scaffold proteins recently identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank polypeptides contain multiple sites for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region, and a SAM domain. Binding partners for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors. The specific localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions. |
